#### Molecular Mechanics Molecular mechanics (MM) is a [traditional computational approach](https://www.eurekaselect.com/65948/article/review-density-functional-theory-quantum-mechanics-applied-pharmaceutically-relevant) when it comes to modeling in synthetic organic chemistry, medicinal chemistry and versatile aspects of drug design. However, MM methods have significant limitations, for example, when used to study electron-based properties within the drug-receptor microenvironment. ##### Quantum Advantage **Quantum mechanical (QM)** methods allow to: --> More accurate predictions --> Much more relevant models of chemical and biological objects and their interactions Advancements driving the direction arrow of progress: - the emergence of density functional theory (DFT) - the overall increase in the computation power - the emergence of distributed cloud-based computational infrastructures [[Drug Types ]]